Proceedings of the National Academy of Sciences of the United States of America

About the PNAS Member Editor
Name Schupbach, Gertrud M.
Location Princeton University
Primary Field Cellular and Developmental Biology
Secondary Field Genetics
 Election Citation
Schupbach has made numerous seminal contributions to understanding oogenesis and embryonic patterning. She co-discovered the vasa gene, and many others required for egg development. Her rigorous molecular analysis of these genes has revealed multiple mechanisms by which somatic tissues interact with the oocyte to establish the embryonic axes.
 Research Interests
Signaling through the ERK pathway regulates many important steps in development. The Schupbach laboratory has studied the EGF receptor in Drosophila oogenesis which is involved in setting up the anterior posterior and dorso ventral axis of the egg and embryo. They determined how a localized signal within the oocyte activates the receptor in a spatially restricted area, and how this localized signal depends on RNA localization and translational control, including in put from a meiotic checkpoint that measures DNA damage as well as retrotransposon activity. The Schupbach laboratory has also studied the polarized secretion of extracellular matrix by the follicle cell epithelium, and the effects of Notch signaling on axis formation. More recently Schupbach has collaborated with the laboratory of Stas Shvartsman at Princeton University in more quantitative approaches to signaling in early embryos of Drosophila, using Drosophila as model system for human mutations in the Ras/Erk pathway.

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