Proceedings of the National Academy of Sciences of the United States of America

About the PNAS Member Editor
Name Clapham, David E.
Location Howard Hughes Medical Institute
Primary Field Cellular and Molecular Neuroscience
Secondary Field Physiology and Pharmacology
 Election Citation
Clapham has contributed immensely to our understanding of calcium ions channels, the most common signal transduction element in cells. Through pioneering studies he has discovered and elucidated the mechanisms regulating a number of novel calcium ion channels, which may potentially lead to the development of drugs that alleviate cardiac arrhythmias.
 Research Interests
Dr. Clapham's major research interest is the signal transduction control of ion channels. This encompasses identification of genes encoding novel ion channels, proteins interacting with these channels, and elucidation of their functions in organelles and the plasma membrane. These studies have included ion channels of mitochondria, lysosomes, ER/nuclear membrane, and cilia as well as many channels on the plasma membranes of diverse tissue from excitable tissues such as brain and heart to spermatozoa.

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