Proceedings of the National Academy of Sciences of the United States of America

About the PNAS Member Editor
Name Bourne, Henry R.
Location University of California, San Francisco
Primary Field Medical Genetics, Hematology and Oncology
 Election Citation
Bourne is an acknowledged leader in the field of intracellular signal transduction. His discoveries have profoundly influenced current views of the regulation of adenylate cyclase by G proteins and the role of mutant G proteins in the pathogenesis of diseases ranging from pseudohypoparathyroidism to endocrine neoplasias.
 Research Interests
Signal transducing (trimeric) G proteins couple sensory and hormonal stimuli to regulation of effector enzymes and ion channels. My laboratory uses tools of molecular genetics, biochemistry, and cell biology to study: the structure and function of trimeric G proteins and the corresponding receptors with the goal of understanding molecular mechanisms of receptor-G protein signaling (protein-protein interactions, conformational change induced by receptor agonists and guanine nucleotides, etc.); signaling pathways mediated by G proteins, with special reference to assigning specific functions to individual G protein subunits; roles of G protein mutations in human diseases (endocrine tumors, pseudohypoparathyroidism); processes that target G protein subunits to correct locations in cells, including covalent linkages to lipids (myristoylation, palmitoylation, prenylation) that control attachment of these subunits to specific membrane compartments, including the plasma membrane; and roles of G proteins and receptors in mediating chemotaxis of neutrophils and other inflammatory cells.

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