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| Name |
Thorner, Jeremy W. |
| Location
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University of California, Berkeley |
| Primary Field
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Biochemistry |
| Secondary Field
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Cellular and Developmental Biology |
 Election Citation
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Thorner dissected proteolytic maturation of alpha-factor pheromone precursor in yeast and discovered the prototype prohormone processing enzyme critical for eukaryotic peptide hormone biogenesis. Then, by studying pheromone response, he identified the first MAP kinase, the first RGS protein, and has made numerous other pathfinding discoveries about cellular signal transduction mechanisms. |
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Research Interests
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Transmembrane and intracellular signal transduction mechanisms have been the main focus of our group, especially understanding how extracellular stimuli control cell growth and division, cell morphology, and gene expression at the biochemical level. Although I have retired from active faculty service (as of 1 July 2020), I will continue to teach (one last time) in academic year 2020-21 and my lab will continue to operate until 30 June 2021 or so, when it will close down permanently. At the present time, we continue to focus most of our remaining research effort on protein kinases that control plasma membrane lipid and protein homeostasis. Previous research projects that, in some cases, are also on-going in collaboration with former graduate students or former postdoctoral fellows, or with collaborators on this campus or elsewhere, include: molecular genetics and biochemistry of MAPK cascades; the roles of septins and septin-associated protein kinases in cell morphogenesis and cell cycle control; and. the molecular biology of phosphoinositide-dependent signaling. |
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