Proceedings of the National Academy of Sciences of the United States of America

About the PNAS Member Editor
Name Goldstein, Joseph L.
Location The University of Texas Southwestern Medical Center
Primary Field Medical Genetics, Hematology and Oncology
Secondary Field Medical Physiology and Metabolism
 Election Citation
Goldstein, together with Michael Brown, discovered the low density lipoprotein (LDL) receptor and worked out how these receptors control cholesterol homeostasis. This research laid the conceptual groundwork for development of the statin drugs that lower blood LDL-cholesterol and prevent heart attacks. It also opened the field of receptor-mediated endocytosis.
 Research Interests
Current research is focused on the following areas: 1) Structure and function of the Scap/SREBP pathway for controlling lipid homeostasis 2) Biochemical pathway in steps by which LDL-derived cholesterol is transported from the lysosome to plasma membrane to endoplasmic reticulum where it carries out its metabolic functions. 3) Elucidating the physiological mechanism by which the blood glucose level is maintained by the Ghrelin-Growth Hormone axis during severe calorie restriction and starvation.

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