Proceedings of the National Academy of Sciences of the United States of America

About the PNAS Member Editor
Name Goldstein, Joseph L.
Location The University of Texas Southwestern Medical Center
Primary Field Medical Genetics, Hematology and Oncology
Secondary Field Medical Physiology and Metabolism
 Election Citation
Goldstein, together with Michael Brown, discovered the low density lipoprotein (LDL) receptor and worked out how these receptors control cholesterol homeostasis. This research laid the conceptual groundwork for development of the statin drugs that lower blood LDL-cholesterol and prevent heart attacks. It also opened the field of receptor-mediated endocytosis.
 Research Interests
Research interests include medical genetics, cholesterol metabolism, and signal transduction and cell regulation.

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