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| Name |
Schimmel, Paul R. |
| Location
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No Affiliation |
| Primary Field
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Biochemistry |
 Election Citation
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Schimmel has been in the forefront of research on a class of enzymes and nucleic acids whose interactions are responsible for the rules of the genetic code. He contributed significantly to the understanding of the structural organization of this class of enzymes, to their mechanism of action, and to the basis for the highly specific recognition between these enzymes and nucleic acids. |
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Research Interests
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Research is focused on the biochemical basis of the genetic code, the origin of the code, and the connection to human diseases. Emphasis is placed on a group of ancient, universal proteins known as aminoacyl tRNA synthetases. These proteins are responsible for the reactions that determine the modern genetic code. In higher organisms, including humans, these proteins have additional functions in signal transduction pathways. Both diseases and therapies for diseases are associated with these proteins. Our work also focuses on how to bring to clinical medicine the results of our research on these proteins. |
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