Proceedings of the National Academy of Sciences of the United States of America

About the PNAS Member Editor
Name Marrack, Philippa
Location National Jewish Health
Primary Field Immunology and Inflammation
 Election Citation
Marrack and Kappler, working as a team, have been preeminent in the study of the molecular basis to T-cell recognition of antigen. Their discoveries have included evidence for a singe two-chain receptor that recognized both a major histocompatibility complex (MHC) molecule and antigen, the characterization of that receptor, and the delineation of the time during development that the genes for the two chains of this receptor rearrange. In addition, they have directly demonstrated that clonal deletion is a major mechanism of induction of T-cell tolerance.
 Research Interests
My research revolves around T cell development, specificity, and function; cellular and molecular immunology; microbial pathogenesis; mammalian development; cell biology; and pathogenicity.

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