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| Name |
Groudine, Mark |
| Location
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Fred Hutchinson Cancer Center |
| Primary Field
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Medical Genetics, Hematology and Oncology |
| Secondary Field
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Cellular and Developmental Biology |
 Election Citation
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Groudine made several seminal contributions to our understanding of how exactly genes are turned on and off in animals. He showed how changes in the structure of chromatin, which comprises chromosomes, help determine whether genes are activated or silenced. In addition, by pinpointing what is required to prompt RNA enzymes to successfully copy gene-containing regions of DNA, he revealed the molecular triggers of various cancers, such as Burkitt's lymphoma. |
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Research Interests
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Groudine's lab uses molecular, biochemical and imaging approaches to understand the mechanisms underlying gene expression, chromatin structure and nuclear organization during differentiation and pathogenesis. During his career, he has contributed to the development of tools to study gene expression and nuclear organization, including use of DNAse I to distinguish different transcription and chromatin states; transcriptional run-ons to determine transcriptional activity, including at the levels of initiation, promoter proximal pausing and elongation; homologous and site-specific recombination to study the contribution of specific factor binding sites in controlling gene expression at their native loci rather than in transgenes; and algorithms to define chromosome adjacencies and the contribution of these adjacencies to gene expression and nuclear organization. The Groudine lab is a rich training environment, and many fellows trained in the laboratory have become leaders in their respective fields. |
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