Proceedings of the National Academy of Sciences of the United States of America

About the PNAS Member Editor
Name Campbell, Kevin P.
Location The University of Iowa
Primary Field Medical Physiology and Metabolism
Secondary Field Physiology and Pharmacology
 Election Citation
Campbell has elucidated the mechanisms that cause various forms of muscular dystrophy. He has identified key components that connect the cell cytoskeleton to the extracellular matrix, and their alterations in health and disease. His studies have profound clinical implications for diagnosing and treating these diseases.
 Research Interests
Research in my laboratory is focused on three main topics. I. Dystrophin-Glycoprotein Complex; II. Muscular Dystrophy and associated Cardiomyopathy; and III. Auxiliary Subunits of Voltage-gated Ca2+ channels. We are continuing to investigate the structure, function and biosynthesis of the dystrophin-glycoprotein complex in order to understand its role in skeletal, cardiac and smooth muscle. In particular, we are interested in the following projects: (1) the role of dystroglycan in basement membrane assembly; (2) the muscle specific disruption of the dystroglycan gene; (3) the biosynthesis and assembly of the sarcoglycan complex; (4) the structural characterization of the DGC in smooth muscle. We are also studying the molecular pathogenesis and possible therapies for the various forms of muscular dystrophy and associated cardiomyopathy. In particular, we are interested in the following projects: (1) the analysis of the molecular pathogenesis of LGMD using sarcoglycan deficient mice; (2) the analysis of cardiolyopathy in d-sarcoglycan deficient mice; and (3) the development of gene transfer theapies for muscular dystrophy and associated cardiomyopathy. Finally, we are continuing to study the auxiliary subunits of voltage-gated Ca2+ channels in order to understand their role in Ca2+ channel function and epilepsy.

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