Proceedings of the National Academy of Sciences of the United States of America

About the PNAS Member Editor
Name Berridge, Michael J.
Location The Babraham Institute
Primary Field Physiology and Pharmacology
 Election Citation
Berridge discovered that extracellular signals mobilize Ca2+ from intracellular stores by stimulating hydrolysis of membrane-bound phosphatidylinositol-4,5-biphosphate. A water soluble intracellular second messenger is generated, inositol trisphosphate, that releases Ca2+ from endoplasmic reticulum. Berridge revolutionized the study of phosphoinositide metabolism and regulation of intracellular Ca2+.
 Research Interests
My main research interest concerns the mode of action of hormones and neurotransmitters at the cellular level, with particular emphasis on the role of calcium as an intracellular second messenger. The problem is to understand how cells detect external signals and translate them into the change in intracellular calcium that is responsible for triggering a wide range of cellular processes, such as contraction, secretion, fertilization, cell growth, and the neuronal mechanisms that regulate membrane excitability, learning, and memory. Current interest is focused on the way in which the second messenger inositol trisphosphate (IP3) functions to release calcium from internal stores. The ability of cells to manipulate these elementary events to create complex spatiotemporal patterns accounts for the versatility of the calcium signaling system.

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