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| Name |
Jin, Yishi |
| Location
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University of California, San Diego |
| Primary Field
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Cellular and Molecular Neuroscience |
| Secondary Field
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Genetics |
 Election Citation
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Jin researches the molecular genetic mechanisms in synapse development and function, as well as the mechanisms protecting and maintaining the mature nervous system. |
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Research Interests
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Yishi Jin's laboratory is interested in the molecular genetic mechanisms in synapse development and function, as well as the mechanisms protecting and maintaining the mature nervous system. Their work is rooted in forward genetic screening approaches in C. elegans. They develop and integrate cutting-edge technologies to rigorously investigate the cellular and molecular signaling pathways, many of which are conserved from C. elegans to mammals. For example, they developed fluorescent reporters for in vivo visualization of synaptic structures and conducted genetic screens that led to the discovery of the core factors in the assembly of the presynaptic active zone. They also provided the first evidence that C. elegans motor circuit synaptic remodeling is under transcriptional regulation and involves multiple dynamic cellular processes. In recent years, they developed laser axotomy technology and established axon regeneration research in C. elegans. Their discovery of the C. elegans DLK-1 kinase pathway in axon regeneration has led to subsequent studies on its homologs in other species, expanding our understanding of this family of kinases in neuronal stress, regeneration and degeneration. They continue to explore fundamental biological questions of broad interest to our understanding of brain function and health. |
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