Proceedings of the National Academy of Sciences of the United States of America

About the PNAS Member Editor
Name Warren, Stephen T.
Location Emory University
Primary Field Medical Genetics, Hematology and Oncology
Secondary Field Cellular and Molecular Neuroscience
 Election Citation
Warren discovered triplet repeat expansion as a new heritable mechanism of disease and the cause of fragile X syndrome. With ~remarkable focus, he elucidated pathways linking repeat expansion to mechanisms of cognitive deficiency, leading to the recognition of classes of drugs with therapeutic potential, culminating in ongoing clinical trials.
 Research Interests
Warren led the international team that discovered the FMR1 gene, responsible for fragile X syndrome, the most common heritable cause of cognitive deficiency. Since that time, his lab has consistently led the field in deciphering the genetics, biochemistry, cell biology and neurobiology of fragile X syndrome. Warren's work has illuminated therapeutic approaches for the treatment of fragile X syndrome, including successful chemical library screens, that have culminated in several ongoing clinical trials. In addition to fragile X syndrome, his laboratory has recently expanded its interest to the genetic determinants of schizophrenia, bipolar disorder, and autism.

 
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