Proceedings of the National Academy of Sciences of the United States of America

About the PNAS Member Editor
Name Bevan, Michael J.
Location University of Washington
Primary Field Immunology and Inflammation
 Election Citation
Bevan discovered many rules governing cytotoxic T cells. He determined the details of antigen presentation, showed that T cells mature in the thymus after exposure to self antigen, and found that helper T cells influence cytotoxic T cells by secreting interleukin-2.
 Research Interests
As a cellular immunologist I study the development of T lymphocytes in the thymus and the response of mature T cells to pathogens. The focus of study is the subset of T cells that bear the CD8 marker and that can kill infected cells expressing their target antigen, so-called cytotoxic T lymphocytes. I noted the phenomenon known as "cross-priming" whereby professional antigen presenting cells, such as dendritic cells, process antigen from foreign or infected cells for presentation to cytotoxic T cells. Also, that the T cell receptor repertoire is positively selected in the thymus by weak interactions with self molecules was first reported by me. More recently, my lab has investigated the requirements for the activation of CD8 T cells, their full effector function and their further differentiation to fuctional memory cells. All of these studies are performed with mice as the model organism.

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