Proceedings of the National Academy of Sciences of the United States of America

About the PNAS Member Editor
Name Weiss, Arthur
Location University of California, San Francisco
Primary Field Immunology and Inflammation
Secondary Field Medical Genetics, Hematology and Oncology
 Election Citation
Weiss is an immunologist who has made major contributions to our understanding of the signaling mechanisms that regulate T lymphocyte development and response. He has identified a novel cytoplasmic tyrosine kinase, defined its role in a congenital immunodeficiency disease, and delineated the mechanisms by which both cytoplasmic tyrosine kinases and transmembrane tyrosine phosphatases control T cell signaling.
 Research Interests
Dr. Weiss' studies have focused on the structure/function of the T cell antigen receptor (TCR). Hi studies on TCR zeta chain chimeras inspired the early development of adoptive tumor immunotherapy with chimeric antigen receptors, now an approved therapy for B cell malignancies. More recently, his lab has focused interest in the roles and regulation of cytoplasmic tyrosine kinases and transmembrane phosphatases. He has studied the influence of dysregulation of tyrosine kinases, particularly of ZAP-70, and phosphatases such as CD45 and CD148 on mouse models of lymphoproliferation, lupus, rheumatoid arthritis, asthma, patient immune deficiency and familial autoimmunity syndromes.

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