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| Name |
Bieniasz, Paul D. |
| Location
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The Rockefeller University |
| Primary Field
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Microbial Biology |
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 Research Interests
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Dr. Bieniasz’s research on retroviruses and, more recently, coronaviruses aims to understand fundamental mechanisms of viral replication, and host defense by innate and adaptive immune systems. These studies involve the discovery and mechanistic exploration of germ-line encoded host proteins such as tetherin, Mx2, ZAP and others that provide intrinsic defense against viral infection. Elucidating mechanisms and evolution of host defense molecules and how viruses evade or antagonize these host defenses provides a basis for understanding host range restriction and a route to deriving novel animal models. The roles of HIV-1 capsid in the HIV-1 replication cycle are being studied, as are mechanisms and regulation of viral genome synthesis and replication, including HIV-1 latency. Escape from neutralizing antibodies is also under study, while antibody and nanobody based antiviral therapeutics are being developed. |
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