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| Name |
Baumler, Andreas J. |
| Location
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University of California, Davis |
| Primary Field
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Microbial Biology |
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 Research Interests
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Dr. Bäumler’s research program investigates mechanisms of intestinal colonization and the host response to Salmonella infection. Since pathogen-induced inflammation results in compositional changes in the gut microbiota, this research identified host factors that balance host-associated microbial communities. The pioneering work in Dr. Bäumler’s laboratory revealed that the cells of the intestinal epithelium regulate the composition and function of our gut microbiota. This research showed that cellular respiration of the intestinal cells and their energy metabolism play an essential role in this. If, for example, the intestinal cells change their metabolism during inflammation, the composition of the microflora changes, resulting in so-called dysbiosis, which can have a decisive influence on the course of the disease, for example in the case of infectious colitis, but also in the case of colorectal cancer or inflammatory bowel disease. These findings provide completely new and original starting points for restoring the balance between microflora and the human body in these diseases. |
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