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| Name |
Weiss, Susan R. |
| Location
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University of Pennsylvania, Perelman School of Medicine |
| Primary Field
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Microbial Biology |
 Election Citation
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Weiss' research includes comparing lethal and common human coronavirus interactions with the host innate immune response and viral antagonists of these antiviral pathways. |
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Research Interests
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Dr Weiss’ research has focused on many aspects of coronavirus replication and pathogenesis, aimed at defining the viral and host determinants of pathogenesis including organ tropism and virulence. This work includes murine coronavirus (MHV) infection of its natural host, used to model encephalitis and demyelinating disease as well as hepatitis and severe acute respiratory disease. More recent studies involve investigation of human coronavirus interactions with the host innate immune responses. The focus has been on activation and antagonism of double-stranded RNA induced antiviral pathways, a crucial determinant of coronavirus replication, spread and pathogenesis. A long-term goal is to identify similarities and differences among the lethal and common cold coronaviruses in order to understand the mechanisms underlying the very different pathogenic outcomes. Other research interests include the antiviral oligoadenylate-ribonuclease L pathway, flavivirus-host interactions and pathogenic effects of host endogenous dsRNA. |
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