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| Name |
Kossiakoff, Anthony A. |
| Location
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The University of Chicago |
| Primary Field
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Biophysics and Computational Biology |
| Secondary Field
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Biochemistry |
 Election Citation
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Kossiakoff uses protein engineering and structure determination to study the biophysical properties underlying molecular recognition processes that trigger and regulate biological functions. |
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Research Interests
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Research interests focus on the structure-function and energetic interrelationships defining the molecular recognition processes that trigger and regulate biological processes. These relationships are addressed using a combination of tools and techniques including protein and antibody engineering, structural biology, directed evolution, synthetic biology, biophysical analyses and cell biology. Developing tools to study functional transient conformational states by structural biology based on customized synthetic antibodies. Methods to enable structure determination of small protein systems by cryo-EM. Receptor-mediated drug delivery. Immuno-based bio-therapeutics: T-cell engineering, engineering universal CARTs systems and plug and play bispecific T-cell engagers. |
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