Proceedings of the National Academy of Sciences of the United States of America

About the PNAS Member Editor
Name Hurley, James H.
Location University of California, Berkeley
Primary Field Biophysics and Computational Biology
Secondary Field Cellular and Developmental Biology
 Election Citation
Hurley has revealed the structural mechanisms underlying autophagy, endosomal and lysosomal protein sorting and signaling, and viral hijacking of membrane traffic.
 Research Interests
Dr. Hurley's lab currently has four major projects in the general area of mechanistic membrane biology. He has a long-standing interest in the core mechanisms of autophagy, and is currently focusing on the structural and biophysical basis of mitophagy and its role in Parkinson?s Disease. He is investigating the mechanism of membrane scission by ESCRT complexes in the contexts of HIV budding and release from infected cells, autophagy, and membrane repair. In a third project, the hijacking of coated vesicle trafficking by HIV is being worked out by structural, reconstitution, and live cell imaging approaches. Lastly, in the newest project, he is using structural and biochemical approaches to study the roles of the lysosomal GTPase regulatory complexes FLCN-FNIP and C9orf72-SMRC8 in neurodegenerative diseases.

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