Proceedings of the National Academy of Sciences of the United States of America

About the PNAS Member Editor
Name Bar-Sagi, Dafna
Location New York University
Primary Field Medical Genetics, Hematology and Oncology
 Research Interests
The major goal of the research carried out in Dafna Bar-Sagi's laboratory is to elucidate the function and regulation of Ras signaling and to understand the biological output of normal and oncogenic Ras proteins. She and her team are interested in defining the contribution of specific molecular perturbations in this signaling axis to cancer initiation and progression with the ultimate goal of utilizing this information for the development of novel diagnostic and therapeutic strategies. Ongoing work in her laboratory includes the development of cell- and animal-based models to study the role of inflammation and immunity in Ras-driven tumorigenesis, the characterization of feedback mechanisms that control the functional output of the Ras signaling axis, the identification of metabolic adaptation processes that enhance tumor fitness, and the use of chemical and nano biology approaches to identify new modalities for therapeutic targeting.

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