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| Name |
Moore, David D. |
| Location
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University of California, Berkeley |
| Primary Field
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Medical Physiology and Metabolism |
 Election Citation
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Moore discovered and cloned the Constitutive Androstane Receptor and other orphan nuclear receptors, uncovering their roles in treating gastrointestinal maladies.
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Research Interests
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David Moore has made seminal discoveries in the roles of nuclear hormone receptors in health and disease. The 48 family members of this superfamily include the steroid receptors and a larger number of proteins termed orphan receptors whose functions and cognate hormones were initially not known. The Moore laboratory's efforts in this field started with the discovery of several orphan family members, including CAR and SHP. He has also contributed to the identification of new ligands and signaling mechanisms, including the discovery of a new class of ligands termed inverse agonists that do not depend on agonist displacement for their inhibitory effects on agonist-independent receptors. More recently, he has focused on the physiologic functions and disease relevance of several orphans and former orphans that act in the liver, including CAR and the bile acid receptor FXR. Following the leads that these and other receptors have provided, he has driven our current understanding of them as key metabolic regulators that maintain healthy homeostasis when they function appropriately, but can drive pathologic responses when dysregulated. |
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