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| Name |
Callaway, Edward M. |
| Location
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Salk Institute for Biological Studies |
| Primary Field
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Systems Neuroscience |
| Secondary Field
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Cellular and Molecular Neuroscience |
 Election Citation
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Callaway's focus on how circuits in the cerebral cortex process information has worldwide applications for schizophrenia, autism, Parkinson's and Huntington's diseases.
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Research Interests
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Edward Callaway's laboratory is interested in the neural mechanisms that give rise to perception and behavior in mammals. Work focuses primarily on vision and the visual cortex, with a focus on identifying the circuits and functional contributions of specific cortical neuron types. The laboratory uses a wide range of experimental approaches. Single-cell genetic and epigenetic profiling is used to identify cell types and to reveal genetic regulatory elements that allow transgene expression to be targeted to cell types of interest. These tools are combined with genetic methods for selective and reversible neuronal activation and inactivation, as well electrophysiology and activity imaging methods to test the impact of activity manipulations on circuit function. Monosynaptic rabies tracing methods first developed in the Callaway laboratory are used to reveal the connectivity of specific cell types. The laboratory has particular interests in cell-type-specific wiring motifs and the roles of specific types of inhibitory cortical neurons in shaping the way that visual information is extracted and encoded by cortical circuits. |
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