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| Name |
Chen, Jue |
| Location
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The Rockefeller University |
| Primary Field
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Biophysics and Computational Biology |
| Secondary Field
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Physiology and Pharmacology |
 Election Citation
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The Chen laboratory studies the structure, mechanism, and regulation of ATP-driven transporters involved in antigen presentation, multidrug resistance, and cystic fibrosis.Â
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Research Interests
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Dr. Chen's research program began with a complete analysis of the structure and mechanism of the bacterial maltose transporter, a nutrient importer that has been extensively studied for more than 40 years as a prototype for ABC transporters. More recently, her laboratory has made major advances in several medically important ABC transporters, including the multidrug transporters
P-glycoprotein and MRP1, TAP (the transporter associated with antigen processing), and CFTR (the cystic fibrosis transmembrane regulator). Their studies uncovered cross-cutting structural principles that underlie how nature utilizes the chemical energy of ATP hydrolysis to perform work-transporting substrates against their chemical gradients. |
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