Proceedings of the National Academy of Sciences of the United States of America

About the PNAS Member Editor
Name Chen, Jue
Location The Rockefeller University
Primary Field Biophysics and Computational Biology
Secondary Field Physiology and Pharmacology
 Election Citation
Chen?s pioneering work on ABC transporters has led to fundamental insights into antigen presentation, multi-drug resistance, and cystic fibrosis.
 Research Interests
Dr. Chen's research program began with a complete analysis of the structure and mechanism of the bacterial maltose transporter, a nutrient importer that has been extensively studied for more than 40 years as a prototype for ABC transporters. More recently, her laboratory has made major advances in several medically important ABC transporters, including the multidrug transporters ~P-glycoprotein and MRP1, TAP (the transporter associated with antigen processing), and CFTR (the cystic fibrosis transmembrane regulator). Their studies uncovered cross-cutting structural principles that underlie how nature utilizes the chemical energy of ATP hydrolysis to perform work-transporting substrates against their chemical gradients.

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