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| Name |
Chen, Chien-Jen |
| Location
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Academia Sinica (Taiwan) |
| Primary Field
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Human Environmental Sciences |
| Secondary Field
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Animal, Nutritional and Applied Microbial Sciences |
 Election Citation
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Chen's discovery of multiple diseases caused by arsenic in drinking water has led to the global mitigation of the largest environmental calamity; his REVEAL-HBV study on natural history and risk prediction of chronic hepatitis B has revised clinical management guidelines internationally as an excellent example of precision medicine. |
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Research Interests
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Chien-Jen Chen's research team is interested in the long-term health risk assessment and molecular and genomic biomarkers of chronic arsenic poisoning and chronic infection of oncogenic viruses. Through large-scale follow-up studies, they have discovered multiple disorders caused by arsenic in drinking water and characterized dose-response relations between ingested arsenic and risk of cancers, vascular diseases, neurological disorders, hypertension, diabetes and cataract. WHO and US EPA have used their findings to set up a new maximal contamination level of arsenic in drinking water to protect health and life of hundred millions of victims. They have documented the efficacy of hepatitis B immunization to prevent fatal hepatic diseases and liver cancer, which has led to the use of vaccines, antivirals or antibiotics to prevent infection-related cancers. Their REVEAL study on the natural history of chronic hepatitis B and C has pioneered the viral load paradigm in clinical management of viral hepatitis, and has developed risk calculators through the combination of host and viral biomarkers to precisely predict long-term risk of diseases induced by oncogenic viruses. |
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