Proceedings of the National Academy of Sciences of the United States of America

About the PNAS Member Editor
Name Glass, Christopher K.
Location University of California, San Diego
Primary Field Medical Physiology and Metabolism
 Election Citation
Glass discovered transcriptional mechanisms that specify macrophage identities and regulate inflammation in cardiovascular, metabolic and neurodegenerative diseases. His work established diverse anti-inflammatory actions of nuclear receptors, explained how broadly expressed transcription factors exert cell-specific functions, and revealed how different tissue environments induce distinct macrophage phenotypes.
 Research Interests
The Glass laboratory has had a long-standing interest in elucidating the molecular mechanisms by which sequence specific transcription factors, co-activators and co-repressors regulate the development and function of macrophages. A major focus has been on understanding the roles of nuclear hormone receptors and other signal dependent transcription factors in controlling programs of gene expression that underlie both their normal homeostatic functions in healthy tissues, as well as their pathogenic functions in the arterial wall, adipose tissue and brain. Recent work from the laboratory uncovered the importance of tissue-specific signals in establishing the diverse macrophage phenotypes observed in different organs. Current studies use a combination of genetics and genomics to define general molecular mechanisms that establish macrophage identity and cell-specific responses to homeostatic and pathogenic signals in both mouse models and human subjects. His laboratory is currently applying these approaches to understand and modify pathological programs of macrophage gene expression that promote the development of atherosclerosis, diabetes, cancer and neurodegenerative diseases.

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