Proceedings of the National Academy of Sciences of the United States of America

About the PNAS Member Editor
Name Glass, Christopher K.
Location University of California, San Diego
Primary Field Medical Physiology and Metabolism
 Election Citation
Glass discovered transcriptional mechanisms that specify macrophage identities and regulate inflammation in cardiovascular, metabolic and neurodegenerative diseases. His work established diverse anti-inflammatory actions of nuclear receptors, explained how broadly expressed transcription factors exert cell-specific functions, and revealed how different tissue environments induce distinct macrophage phenotypes.
 Research Interests
The primary goal of my laboratory is to understand the mechanisms by which sequence-specific transcription factors, co-activators and co-repressors regulate the development and function of macrophages in health and disease. A major direction over the past five years has been to define the genome-wide locations and functions of these proteins through the use of assays that are based on massively parallel DNA sequencing. The combination of these technologies with molecular, genetic, lipidomic and cell-based approaches is providing new insights into mechanisms that regulate macrophage gene expression and function that are relevant to a broad range of devastating human disorders for which treatments are not available or are ineffective. One of most important recent efforts has been to define the transcriptomes and regulatory landscapes of human microglia in order to better understand pathogenic mechanisms underlying Alzheimer's Disease.

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