Proceedings of the National Academy of Sciences of the United States of America

About the PNAS Member Editor
Name Meng, Xiang-Jin
Location Virginia Polytechnic Institute and State University
Primary Field Animal, Nutritional and Applied Microbial Sciences
Secondary Field Microbial Biology
 Election Citation
Hepatitis E was long known as a human disease. Meng's discovery of two animal hepatitis viruses revolutionized the field and led a paradigmshift that recognized hepatitis E as a zoonotic disease transmissible from animals to humans. Meng also developed the first USDA-licensed vaccine against porcine circovirus, a deadly emerging virus.
 Research Interests
X.J. Meng's laboratory focuses on studying the molecular mechanisms of viral pathogenesis and developing effective vaccines against emerging, re-emerging, and zoonotic viral diseases of veterinary and human public health importance. Viruses currently being studied in the Meng's lab include the hepatitis E viruses (HEV), porcine circovirus type 2 (PCV2), porcine reproductive and respiratory syndrome virus (PRRSV), torque teno sus virus (TTSuV), porcine mammalian orthoreovirus type 3 (MRV3), and porcine epidemic diarrhea virus (PEDV). Meng's work has led to the development of the first U.S. Department of Agriculture fully-licensed vaccine against porcine circovirus type 2, which is now being used worldwide. Meng's research also led to the discovery of the first animal strain of hepatitis E virus, now known as the swine hepatitis E virus. By using novel animal models they help developed for the hepatitis E virus, the Meng lab is studying the mechanisms of HEV replication and pathogenesis, define the mechanisms of HEV cross-species infection, and develop vaccines against HEV. Additionally, by using reverse genetics systems, the Meng lab is studying the structural and functional relationship of virus genes for a number of important veterinary viruses.

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