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| Name |
Goodnow, Christopher C. |
| Location
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Garvan Institute of Medical Research |
| Primary Field
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Immunology and Inflammation |
| Secondary Field
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Medical Genetics, Hematology and Oncology |
 Election Citation
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Goodnow illuminated the mechanism of immunological self-tolerance through innovative integration of mouse molecular genetics with cellular immunology. His discoveries changed concepts of how self-tolerance is acquired, revealing that self-reactive lymphocytes are controlled by a series of checkpoint mechanisms at each step in the process that leads to antibody formation. |
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Research Interests
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Chris? research focuses on understanding the cause of autoimmune diseases and the control mechanisms that normally guide formation of antibodies with desirable specificity, affinity and solubility. His team integrates genetics and genomics technologies with single cell analysis of immune cells and antibodies in people and in mouse models. A key focus is on identifying germline and somatic mutations that allow cells to circumvent immune tolerance checkpoints and produce autoantibodies. His research interests extend to the pathogenesis and targeted therapies for lymphoma and leukemia, and identifying immune tolerance checkpoint inhibitors for cancer immunotherapy. |
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