Proceedings of the National Academy of Sciences of the United States of America

About the PNAS Member Editor
Name Chang, Yuan
Location University of Pittsburgh
Primary Field Microbial Biology
Secondary Field Medical Genetics, Hematology and Oncology
 Election Citation
Chang is the leader of a team whose seminal studies led to the isolation and initial characterization of a new human herpesvirus associated with Kaposi's sarcoma and more recently of a new human polyomavirus that serves as a marker and likely causative agent of Merkel cell carcinomas.
 Research Interests
Our laboratory identified two of the seven known human tumor viruses: Kaposi's sarcoma associated herpesvirus (KSHV/HHV-8) and Merkel cell polyomavirus (MCV). We are involved in basic and applied research on viral oncogenesis with efforts focused in the following three areas: 1) Merkel cell polyomavirus (MCV) is etiologically associated with Merkel cell carcinoma (MCC), one of the most clinically aggressive skin cancers in humans. We are engaged in the investigation of viral T oncoproteins and their role in transformation and replication. 2) Kaposi's sarcoma-associated herpesvirus. through extensive molecular piracy, has incorporated numerous genes that affect cell proliferation pathways, apoptosis, cell cycle regulation and immune modulation. Our laboratory studies how these viral proteins affect host cell signaling pathways. 3) New Pathogen Discovery. We continue to be interested in the search for new pathogens in human diseases and have developed methodologies that utilize information gained from the Human Genome Project combined with advanced sequencing and proteomic technologies.

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