Proceedings of the National Academy of Sciences of the United States of America

About the PNAS Member Editor
Name Lee, Sang Yup
Location KAIST (Korea Advanced Institute of Science & Techn
Primary Field Engineering Sciences
Secondary Field Microbial Biology
 Election Citation
Lee pioneered the integration of metabolic engineering with systems biology and synthetic biology, leading to the development of the field of systems metabolic engineering. His seminal, systems-based approaches established general strategies for developing various microorganisms and bioprocesses efficiently producing chemicals and materials, many for the first time, from renewable resources.
 Research Interests
Sang Yup Lee's laboratory is interested in metabolic engineering of microorganisms for the production of chemicals and materials, either natural or non-natural, from renewable non-food biomass. In particular, they established systems metabolic engineering that integrates systems biology, synthetic biology and evolutionary engineering with traditional metabolic engineering. They have developed a number of platform metabolic engineering strategies including computational algorithms for target identification and synthetic small RNA-based genome-wide metabolic engineering tool. They developed a highly efficient succinic acid producing bioprocess based on a rumen bacterium, and developed for the first time bioprocesses for fermentative production of gasoline, polylactic acid, poly (lactate-co-glycolate), terephthalic acid, diamines for engineering plastics, among others. They have also been interested in production of various pharmaceutical proteins and material proteins such as ultra high Mw spider silk protein. They have also been active in studying systems biology of human cellular network, pathogenic microorganisms, and also traditional oriental medicine. They also developed diagnostic systems for pathogens and human diseases, and are working on human systems biology. Lee also runs a scientific section on new bioactive compounds at DTU NNF Center for Biosustainability, Denmark, where his team works on the discovery and metabolic engineering of antibiotics and functional natural compounds.

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