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| Name |
Garcia-Sastre, Adolfo |
| Location
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Icahn School of Medicine at Mount Sinai |
| Primary Field
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Microbial Biology |
| Secondary Field
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Immunology and Inflammation |
 Election Citation
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GarcÃa-Sastre discovered that RNA viruses encode proteins that inhibit microbial sensing and are essential for virulence by antagonizing interferon.
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Research Interests
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Research in the GarcÃa-Sastre laboratory focuses on a wide variety of viral pathogens, as well as host-pathogen interactions, and vaccine and anti-viral drug development. A major focus of the lab is on influenza virus research. Influenza viruses are globally important human pathogens infecting up to 500 million people annually. With the emergence of highly pathogenic avian influenza strains, there is a pressing need to understand the pathogenesis of influenza A and develop better vaccines and therapies. The laboratory is using both hypothesis-driven and systems biology based approaches to understand virus pathogenesis and to develop improved antivirals and vaccines. These studies are also geared towards the identification of novel regulators of innate and adaptive immune responses leading to the development of new vaccines and therapies against infectious diseases and cancer. Specifically, they are working in understanding the factors associated with severe influenza virus infection, the development of pan-influenza virus vaccines, the discovery of novel adjuvants, and the use of engineered viruses as vaccine vectors and as anti-tumor agents. |
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