Proceedings of the National Academy of Sciences of the United States of America

About the PNAS Member Editor
Name Brown, Emery N.
Location Massachusetts Institute of Technology
Primary Field Systems Neuroscience
Secondary Field Applied Mathematical Sciences
 Election Citation
Brown, anesthesiologist-statistician, has made fundamental contributions to understanding the neurophysiology of the brain under general anesthesia. He has developed state-space point process algorithms to decode spatial information in ensemble spiking activity of hippocampal place cells, characterize receptive field formation, and control in real-time neural prosthetics and anesthetic states.
 Research Interests
Emery N. Brown has developed the state-space point process paradigm to solve neuroscience data analysis challenges: decode how neurons dynamically represent information in their group spiking activity; characterize neural receptive field formation, neural activity during motor learning, and behavioral changes during learning; and develop control systems for neural prosthetics and for anesthesia delivery. Brown co-founded and co-directed the Woods Hole Neuroinformatics summer course and the biannual Carnegie-Mellon Statistical Analysis of Neural Data workshop. He co-authored the neuroscience statistics textbook, Analysis of Neural Data (Springer, 2014). Brown established and leads an interdisciplinary team at MGH, MIT and Boston University which has developed: the first detailed neurophysiological descriptions of anesthetic mechanisms; new strategies for monitoring and controlling the anesthetic states of the brain; and ways to rapidly induce emergence from general anesthesia and sedation. The research is developing personalized, side-effect-free anesthesia care firmly rooted in neuroscience.

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