Proceedings of the National Academy of Sciences of the United States of America

About the PNAS Member Editor
Name Bhatia, Sangeeta N.
Location Massachusetts Institute of Technology
Primary Field Engineering Sciences
 Election Citation
Bhatia pioneered technologies to interface cells with synthetic systems, with applications in tissue regeneration, stem cell differentiation, diagnostics and drug delivery. She developed human microlivers which model drug metabolism and liver disease, achieving novel high-throughput models that fully replicate the life cycles of hepatitis C and liver-stage human malaria.
 Research Interests
The focus of Sangeeta Bhatia's research is on the development of novel micro- and nanoscale platforms for understanding, diagnosing, and treating human disease. While cell autonomous processes certainly influence the balance between health and disease, the laboratory's focus is on interactions between cells and their microenvironment. They leverage micro- and nanotechnology tools that have been created by the semiconductor community, which, by virtue of their spatial resolution, enable the precise synthesis, interrogation, and perturbation of tissue microenvironments. Specifically, they focus on tissue microenvironments of clinical importance in hepatology and oncology. In the area of hepatology, they are interested in liver tissue engineering - both for treating patients with cell-based therapies and for developing more predictive in vitro models of human disease. In the oncology field, they leverage the physical traits of nanomaterials to improve the diagnosis and treatment of tumors. The Bhatia group endeavors to translate their inventions and scientific findings to patients, and to advocate for diversity in science and engineering.

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