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| Name |
Tycko, Robert |
| Location
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No Affiliation |
| Primary Field
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Biophysics and Computational Biology |
| Secondary Field
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Applied Physical Sciences |
 Election Citation
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Tycko developed and applied new magnetic resonance methods to transform our understanding of amyloid fibril structures, including those associated with Alzheimer's disease. |
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Research Interests
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Robert Tycko's research group is currently pursuing several distinct but inter-related projects. Members of his group are using solid state nuclear magnetic resonance (ssNMR) and electron microscopy to characterize molecular structures of amyloid-B fibrils, including fibrils that develop in brain tissue of Alzheimer's disease patients. They are also investigating molecular structures of amyloid-like fibrils formed by low-complexity protein sequences, with the goal of understanding the biologically relevant self-assembly behavior of such sequences. They are developing time-resolved ssNMR methods that allow detailed structural studies of transient intermediates in biomolecular processes such as protein folding, ligand binding, and protein aggregation, on the millisecond time scale. They are also developing ultra-low-temperature methods for sensitivity enhancement in biomolecular ssNMR and for resolution enhancement in magnetic resonance imaging (MRI), with the goal of achieving sub-micron resolution in MRI of cells and cell clusters. |
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