Proceedings of the National Academy of Sciences of the United States of America

About the PNAS Member Editor
Name Taniguchi, Tadatsugu
Location University of Tokyo
Primary Field Immunology and Inflammation
Secondary Field Medical Genetics, Hematology and Oncology
 Election Citation
From Japan, Taniguchi has performed groundbreaking research in molecular immunology. He was the first to isolate and characterize an interferon gene, and he discovered the interferon regulatory family of transcription factors. He has also characterized the key regulator of immune responses, interleukin-2, and elucidated its mechanism of action.
 Research Interests
My research career in Immunology began with the original identification of two cytokine genes and their characterization between the late 1970s and early 1980s, namely, the genes encoding human fibroblast interferon (now known as IFN-b) and interleukin-2 (IL-2). The molecular identification of the products of these and other cytokine genes, carried out by us and many others, made it possible to study their functional properties and elucidate their intracellular signaling mechanism as well as their physiological regulation. These initial studies have led us to further extend the characterization of these cytokine systems in the context of the regulation of immunity and oncogenesis. One of our major contributions is the discovery and characterization of a new family of transcription factors, termed interferon regulatory factors (IRFs). Our current research interests are aimed at clarifying the function and regulation of the IRF family of transcription factors in oncogenesis and immunity. In addition, we also focus on the mechanism of signaling and transcription networks elicited by IFN-a/b and other cytokines, important in the immune responses to pathogens and cancer.

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