Proceedings of the National Academy of Sciences of the United States of America

About the PNAS Member Editor
Name Goff, Stephen P.
Location Columbia University
Primary Field Microbial Biology
Secondary Field Biochemistry
 Election Citation
Goff is widely known for several major developments in the study of retroviruses in mice and humans. He focuses on the function of viral gene products and the host proteins with which the viruses interact.
 Research Interests
Dr. Goff and his colleagues are analyzing the replication of the mammalian retroviruses, including the murine leukemia viruses (MuLVs) and the human immunodeficiency virus (HIV-1), to define the functions of each of the viral gene products and to identify host proteins with which the viruses interact. Dr. Goff's laboratory has used in vitro mutagenesis to identify portions of the viral proteins required for each step in the virus life cycle. These mutational studies have addressed the functions of the virion structural proteins (encoded by the Gag gene), as well as reverse transcriptase (RT) and integrase (IN). A major area of study in the laboratory is the use of somatic cell genetics and the two-hybrid system to identify host proteins involved in virus replication. Current efforts are focussing on the characterization of several novel host proteins that interact with the Gag, Pol, and Env gene products of the virus. Several of these proteins are important for efficient virus replication and serve to promote various steps in the life cycle. Others have been found to inhibit or restrict virus replication and thus serve as components of the innate immune system. Recent work has helped define the machinery responsible for silencing retroviral transcription in embryonic stem cells.

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