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| Name |
Vogt, Peter K. |
| Location
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Scripps Research |
| Primary Field
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Microbial Biology |
 Election Citation
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Not available |
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Research Interests
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Peter Vogt's laboratory studies the genetic and epigenetic mechanisms that induce oncogenic transformation of cells and has conducted screens for small molecules that intervene with the activity of newly identified cancer targets. The current research focuses on: 1) Protein and lipid kinases: PI3K is an important cancer target. The Vogt lab has characterized the cancer-specific mutations in PI3K and continues to explore basic signaling mechanisms that involve this kinase. They are particularly interested in non-redundant, isoform-specific activities of Class IA PI3K and the characterization of novel specific inhibitors that interfere with oncogenic PI3K. 2) Transcriptional regulators: The work on gene transcription centers on Myc and is currently focused on a compound identified from a Krohnke pyridine library (collaboration with Kim Janda) that binds to Myc, inhibits Myc-induced oncogenic transformation in vitro and in vivo and extinguishes the Myc transcriptional signature. 3) Non-coding, antisense RNA: LncRNAs are critical in the epigenetic regulation of gene activity. The Vogt lab has discovered that Myc controls the expression of most lncRNAs. Using a CRISPR-based screen, they have identified numerous lncRNAs that are required for Myc-driven cell proliferation and are in the process of characterizing the functions of these transcripts. |
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