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| Name |
Chibale, Kelly |
| Location
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University of Cape Town |
| Primary Field
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Animal, Nutritional and Applied Microbial Sciences |
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 Research Interests
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Dr Chibale’s research interests are in infectious disease drug discovery and the development of technologies to contribute to improving treatment outcomes in people of African descent. The drug discovery research focuses on the causative agents of malaria (Plasmodium falciparum), tuberculosis (Mycobacterium tuberculosis) and antibiotic-resistant microbial diseases (ESKAPE pathogens). The research integrates chemistry, biology and pharmacology, including drug metabolism and pharmacokinetics, to identify preclinical drug development candidates. As part of the programs, mechanism of action studies through target identification are also conducted. Within the context of development of technologies to contribute to improving treatment outcomes in people of African descent, pharmacogenomics research is conducted in terms of evaluating the impact of variable genetics on drug pharmacokinetics in African populations. Artificial intelligence (AI) and machine learning are used in the drug discovery programs and coupled to pharmacometrics modelling to tailor drug dosages in pharmacogenomics research aspects. |
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