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| Name |
Abate-Shen, Cory |
| Location
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Columbia University Vagelos College of Physicians and Surgeo ns |
| Primary Field
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Medical Genetics, Hematology and Oncology |
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 Research Interests
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Cory Abate-Shen has a long-standing interest in understanding how processes underlying normal development go awry in cancer. Her discovery that Nkx3.1 is a prostate-specific homeobox gene led to the finding that NKX3.1 is sufficient to specify prostate in vivo, one of the few cases in which a single gene can re-program an otherwise fully differentiated tissue. Analyses of mutant mice showed the role of NKX3.1 loss in prostate cancer initiation and resulted in genetically engineered mouse models (GEMMs) that represent a broad spectrum of prostate cancer phenotypes. These models led to the identification of lineage plasticity as a key mechanism of drug resistance in neuroendocrine prostate cancer, and elucidation of new mechanisms of bone metastasis. She has generated genome-wide regulatory networks for mouse and human prostate cancer that have enabled cross-species computational analyses to identify master regulators of disease progression and metastasis. In addition to her work in prostate cancer, her laboratory has developed a toolkit to target the bladder urothelium in vivo, resulting in GEMMs that have informed on the cell of origin of bladder cancer and functional roles of key tumor suppressors for disease progression. Notably, analyses of these GEMMs have informed clinical practice through co-clinical analyses of combination chemotherapy which has proven beneficial for patients with high-risk non-muscle invasive bladder cancer. |
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