Proceedings of the National Academy of Sciences of the United States of America

About the PNAS Member Editor
Name Clark, Andrew G.
Location Cornell University
Primary Field Evolutionary Biology
Secondary Field Genetics
 Election Citation
Clark used comparative genomics to identify many of the key genes under selection in the human and chimpanzee lineages. He discovered how to analyze "heterochromatic" genes in unassembled sequence traces, and carried out pioneering studies of complex multigenic traits in Drosophila including metabolic regulation, sperm competition, and bacterial resistance.
 Research Interests
Andrew Clark is a population geneticist whose lab has contributed to several areas of Drosophila and human evolutionary genetics and genomics. The Drosophila work centers on complex traits, including innate immune response, lipid metabolism and storage, and sperm competition. His lab has quantified DNA sequence polymorphism in relevant genes and produced models that seek to explain variation in endpoint phenotypes that arise as a consequence of variation in genes in the respective pathways. His group has also developed methods for identification of Y-linked genes embedded in heterochromatin. His lab played a key role in pulling together the Drosophila 12 genomes analysis and publication. His work in the area of human population genomics has focused on context-dependent genetic variation associated with cardiovascular disease risk, on inference of haplotype phase, and on the use of genome-wide SNP data to make inferences about past action of natural selection and demographic changes. Most recently this has turned to analysis of very recent explosive population growth and its consequent influx of rare variation. In addition, he has pursued RNA-sequencing in reciprocal crosses of many organisms as a tool for elucidating genomic imprinting and X-inactivation.

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