Proceedings of the National Academy of Sciences of the United States of America

About the PNAS Member Editor
Name Moore, Peter B.
Location Yale University
Primary Field Biophysics and Computational Biology
Secondary Field Biochemistry
 Election Citation
Moore has pioneered the development of novel biophysical approaches for obtaining structural information on macromolecules and their assemblies. His neutron scattering analyses of the ribosome and NMR structure determinations of ribosomal RNA fragments have enlightened biological understanding of structure-function relationships in RNA machines.
 Research Interests
The structure of biological macromolecules and macromolecular assemblies has been the focus of my research for many years. I started working in this area while I was a postdoctoral fellow at the MRC Laboratory of Molecular Biology (U.K.) where I helped deduce the structures of muscle filaments from electron micrographs using the then novel method three-dimensional reconstruction. Shortly after joining the faculty at Yale, and in collaboration with D.M. Engelman, I began determining the positions of proteins in the small ribosomal subunit using a novel method that depended on neutron scattering. This project consumed most of our resources for 15 years. Around 1980, the focus of the laboratory started shifting from low resolution approaches to macromolecular structure to high resolution methods. Since then, we have determined the solution structures of several RNAs by nuclear magnetic resonance. We have also been studying some of the macromolecules involved in protein synthesis crystallographically. The most intriguing of the crystallographic projects now under way is a collaboration with T.A. Steitz, the objective of which is the determination of the crystal structure of the large ribosomal subunit.

 
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