Proceedings of the National Academy of Sciences of the United States of America

About the PNAS Member Editor
Name Oldstone, Michael B.
Location The Scripps Research Institute
Primary Field Microbial Biology
Secondary Field Immunology and Inflammation
 Election Citation
Oldstone pioneered the field of viral immunology, and established how viruses suppress the immune system to cause a persistent infection. His research has also elucidated how viruses activate the immune system to cause autoimmunity.
 Research Interests
I pioneered the field of viral immunology and have been a leader in viral pathogenesis and immunity for the past four decades. I am known for my work studying the interaction of the arenavirus lymphocytic choriomeningitis virus with its natural murine host as well as investigations of measles virus. My observations indicated how viruses induce suppression of the immune system to cause a persistent infection and how viruses activate the immune system to cause autoimmunity. I have defined the parameters of the formation and consequences of virus-antiviral antibody immune complex deposits leading to disease, host molecules like IL-10 that the virus induces to suppress the immune system and the description and consequences of how a persistent virus infects differentiated cells, alters their function, disturbs homeostasis and cause disease.

 
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