Proceedings of the National Academy of Sciences of the United States of America

About the PNAS Member Editor
Name Koshland, Douglas E.
Location University of California, Berkeley
Primary Field Genetics
 Election Citation
Koshland has uncovered mechanisms that govern chromosome cohesion and structural transitions. He was the first to identify cohesins, made major contributions to the understanding of cohesins and condensins, and employed minichromosomes to illuminate universal chromosome transitions and the specific proteins involved.
 Research Interests
My laboratory uses genetic, cell biological and biochemical approaches in budding yeast to understand genome integrity, genome evolution and most recently desiccation tolerance. The maintenance of genome integrity during cell division impacts cell viability, speciation, birth defects and human disease. The maintenance of genome integrity (chromosome number and integrity) requires different types of higher order chromosome organization. The molecular basis for the formation, maintenance and disassembly of higher order chromosome organization are major unsolved problems in cell biology. While processes like higher order chromsome organization, DNA replication and DNA repair are known to be critical for genome integrity, genome integrity is likely to require other yet to be describe processes. For example the cause of the gross chromosomal rearrangements (GCR) such as translocations, internal deletions or terminal truncations, prevalent in the vast majority of tumor cells is unknown. Finally, understanding desiccation tolerance has significant biomedical potential and will likely provide novel insights into the role of different cell biological processes in water homeostasis. While the molecular basis of desiccation tolerance has been correlated with many factors and phenomena, none of these proteins or processes have been shown to have a causative role.

 
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