Proceedings of the National Academy of Sciences of the United States of America

About the PNAS Member Editor
Name Chen, Chien-Jen
Location Office of the President, Republic of China (Taiwan
Primary Field Human Environmental Sciences
Secondary Field Animal, Nutritional and Applied Microbial Sciences
 Election Citation
Chen's discovery of multiple diseases caused by arsenic in drinking water has led to the global mitigation of the largest environmental calamity; his REVEAL-HBV study on natural history and risk prediction of chronic hepatitis B has revised clinical management guidelines internationally as an excellent example of precision medicine.
 Research Interests
Chien-Jen Chen's research team is interested in the long-term health risk assessment and molecular and genomic biomarkers of chronic arsenic poisoning and chronic infection of oncogenic viruses. Through large-scale follow-up studies, they have discovered multiple disorders caused by arsenic in drinking water and characterized dose-response relations between ingested arsenic and risk of cancers, vascular diseases, neurological disorders, hypertension, diabetes and cataract. WHO and US EPA have used their findings to set up a new maximal contamination level of arsenic in drinking water to protect health and life of hundred millions of victims. They have documented the efficacy of hepatitis B immunization to prevent fatal hepatic diseases and liver cancer, which has led to the use of vaccines, antivirals or antibiotics to prevent infection-related cancers. Their REVEAL study on the natural history of chronic hepatitis B and C has pioneered the viral load paradigm in clinical management of viral hepatitis, and has developed risk calculators through the combination of host and viral biomarkers to precisely predict long-term risk of diseases induced by oncogenic viruses.

 
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