Proceedings of the National Academy of Sciences of the United States of America

About the PNAS Member Editor
Name Goodnow, Christopher C.
Location Garvan Institute of Medical Research
Primary Field Immunology and Inflammation
Secondary Field Medical Genetics, Hematology and Oncology
 Election Citation
Goodnow illuminated the mechanism of immunological self-tolerance through innovative integration of mouse molecular genetics with cellular immunology. His discoveries changed concepts of how self-tolerance is acquired, revealing that self-reactive lymphocytes are controlled by a series of checkpoint mechanisms at each step in the process that leads to antibody formation.
 Research Interests
Goodnow employs genome-wide mutation analysis as a principle tool to understand self-nonself discrimination by the immune system and illuminate the pathogenesis of autoimmune diseases, allergic diseases, immune deficiency diseases and cancer. In inbred laboratory mice, he and his collaborators conduct large-scale genetic screens to reveal new genes and mechanisms of immune disease, successfully integrating whole exome and whole genome sequence analysis with cellular immunology. Recently, he and his collaborators have successfully initiated a parallel approach to analyze immunological disease in humans, taking into account the much higher rate of mutations by integrating whole exome sequence analysis with immune cell analysis and the capacity to test disease causation and mechanisms in mice.

 
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