Proceedings of the National Academy of Sciences of the United States of America

About the PNAS Member Editor
Name Duboule, Denis
Location University of Geneva
Primary Field Cellular and Developmental Biology
 Election Citation
Hox genes are critical for patterning the rostrocaudal axis of developing embryos. Using elegant methods by which the global organization of the Hox gene cluster is altered, Duboule showed how Hox genes are organized and function in vertebrates. His work has been pivotal in understanding genomic control of vertebrate development.
 Research Interests
Duboule's research activities are in the fields of embryology, genetics and developmental genomics of mammals, in an evolutionnary context. In particular, his laboratory has been closely associated with the structural and functional studies of mammalian Hox genes, by using mouse molecular genetic approaches. For the past many years, the main aim of the laboratory is to understand how the transcription of Hox genes is coordinately regulated, during development, such as to promote a coherent organization of structures, and how such regulatory capacities have evolved along with the emergence of the vertebrate lineage.

 
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