Proceedings of the National Academy of Sciences of the United States of America

About the PNAS Member Editor
Name Barbacid, Mariano
Location Spanish National Cancer Research Center (CNIO)
Primary Field Medical Genetics, Hematology and Oncology
 Election Citation
Barbacid?s main accomplishments include isolation and establishment of the mechanism of activation of the H-Ras human oncogene; demonstration that oncogenes are targets of chemical carcinogens; isolation and functional characterization of the Trk family of neurotrophin receptors; and redefinition of the role of interphase Cdks in the mammalian cell cycle.
 Research Interests
His research interests currently focus on the design of new animal models of cancer that faithfully recapitulate the natural history of the corresponding human tumors and on the identification and validation of molecular targets with potential therapeutic value. Briefly, his laboratory has generated genetically engineered mouse (GEM) models for lung and pancreatic tumors driven by K-Ras oncogenes, two types of malignancies for which there are no efficacious medicines. Then, the Barbacid lab systematically inactivates targets of potential therapeutic value by manipulating the genome of these tumored mice to ultimately determine whether inactivation of these targets prevents or at least compromises tumor development. Moreover, since these targets are eliminated systemically, these experiments provide critical information regarding potential mechanism-based toxicities. Results derived from these studies are opening the door to the design selective inhibitors against those targets shown to have significant anti-tumor effect in these GEM models.The Barbacid lab is also interested in developing mouse model for RASopathies, a series of developmental disorders caused by abnormal activation of the RAS signaling pathway during embryonic development and to dissect, by genetic means, the mechanism(s) by which the RAS/RAF/MEK/ERK pathway mediates mitogenic signalling during normal homeostasis.

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