Proceedings of the National Academy of Sciences of the United States of America

About the PNAS Member Editor
Name Steinman, Lawrence
Location Stanford University
Primary Field Immunology and Inflammation
Secondary Field Cellular and Molecular Neuroscience
 Election Citation
Steinman made groundbreaking discoveries on the molecular basis for relapsing multiple sclerosis. He first showed that a4 integrin was critical for lymphocyte homing to MS brain. He then helped design trials testing a4 integrin blockade, which showed dramatic reductions in relapses, leading to the most effective approved therapy for MS.
 Research Interests
Steinman is interested in the pathogenesis of multiple sclerosis and related neuroinflammatory diseases. A major translational focus is the development of antigen specific tolerance therapy for autoimmune diseases where the autoantigen is clearly defined, particularly type 1 diabetes and neuromyelitis optica. His laboratory is also interested in the pathogenesis and therapy of those diseases where amyloid structures are at the center of attention in pathogenesis, including Huntington's Disease and Alzheimer's. Research on the unique anti-inflammatory properties of basic amyloid forming nanostructures has emanated from this interest.

 
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