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| Name |
Olson, Eric N. |
| Location
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The University of Texas Southwestern Medical Center |
| Primary Field
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Cellular and Developmental Biology |
| Secondary Field
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Biochemistry |
 Election Citation
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Olson mastered the integrated use of biochemical, genetic, and molecular biological methods to resolve how tissues are determined and differentiated in multicellular organisms. Olson unveiled the most compelling description of how myogenic and cardiogenic transcription factors control organogenesis of skeletal muscle and heart tissues in fruit flies and laboratory mice. |
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Research Interests
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My primary research interest is in the molecular mechanisms that control cell destiny during development. To approach this problem my laboratory has studied muscle cells and has discovered a series of developmental control genes that govern muscle cell identity and differentiation. Because the basic mechanisms for muscle development are evolutionarily conserved, it has been possible to use the fruit fly as a simple model system to learn about more complex developmental control mechanisms in mammals. It has recently become clear that many of the gene regulatory proteins and signaling molecules that control cardiac muscle development are also important for remodeling the adult heart during pathologic cardiac enlargement and heart failure. Thus, deciphering the molecular mechanisms that regulate cardiac development and gene expression in model organisms has yielded insights into the molecular bases for congenital and acquired heart disease in humans and is opening opportunities for genetic and pharmacologic modification of cardiac form and function. |
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